come on, dude.
(1) How to Make LAN cables.
If you need remote access to our server, make your own LAN cable first.
We are looking for highly motivated graduate students who are interested in neuroimaging, neural engineering, and neurosciences.
■ Engineering, Natural Science, and/or Medicine backgrounds are preferred.
■ The major for the degree would be MS/PhD in engineering (biomedical engineering) or in medicine (physiology).
■ Full or partial supports for tuition, space, and devices are available from government-funded research projects.
■ Internship is also available without support.
■ We DO NOT have any program for supporting international students.
Please send an email with a brief curriculum vitae to email@example.com.
We recently got the new nest in the Fusion Technology Center (FTC).
Jean Kwon (visiting student from Columnbia University) published her first paper in IJMS. This study was accomplished by collaboration with Prof. Sung Jun Jung’s lab. in the Dept. of Physiology.
Link to the text: https://www.mdpi.com/1422-0067/22/24/13534
Cyclooxygenase metabolizes dihomo-γ-linolenic acid and arachidonic acid to form prostaglandin (PG) E, including PGE1 and PGE2, respectively. Although PGE2 is well known to play an important role in the development and maintenance of hyperalgesia and allodynia, the role of PGE1 in pain is unknown. We confirm whether PGE1 induced pain using orofacial pain behavioral test in mice and determine the target molecule of PGE1 in TG neurons with whole-cell patch-clamp and immunohistochemistry. Intradermal injection of PGE1 to the whisker pads of mice induced a reduced threshold, enhancing the excitability of HCN channel-expressing trigeminal ganglion (TG) neurons. The HCN channel-generated inward current (Ih) was increased by 135.3 ± 4.8% at 100 nM of PGE1 in small- or medium-sized TG, and the action of PGE1 on Ih showed a concentration-dependent effect, with a median effective dose (ED50) of 29.3 nM. Adenylyl cyclase inhibitor (MDL12330A), 8-bromo-cAMP, and the EP2 receptor antagonist AH6809 inhibited PGE1-induced Ih. Additionally, PGE1-induced mechanical allodynia was blocked by CsCl and AH6809. PGE1 plays a role in mechanical allodynia through HCN2 channel facilitation via the EP2 receptor in nociceptive neurons, suggesting a potential therapeutic target in that PGE1 could be involved in pain as endogenous substances under inflammatory conditions.